In recent years, the popularity of injectable treatments like Botox and Xeomin has skyrocketed, and for a great reason. They’re unbeatable at erasing expression wrinkles, but their capability extends further – they can address excessive sweating or relax a clenching jaw. In this post, we’ll compare Botox vs Xeomin, explaining the differences and similarities between these two anti-aging powerhouses. 


What Are the Differences Between Xeomin and Botox?

Xeomin (incobotulinumtoxinA) and Botox (onabotulinumtoxinA) are both injectable treatments that work by halting muscle contractions, softening wrinkles like frown lines and crow’s feet. 

The two treatments are remarkably similar, but there are a few key differences you should know about. 


Production Process

Both Botox and Xeomin are produced from the botulinum toxin type A. The toxin undergoes processing and filtering which results in a controlled dose. The resultant material from the Botox filtering process is a crystalline complex of the toxin and trace proteins. 

Xeomin undergoes an additional filtration process that removes complex proteins, which results in a purer material that’s moremost stable and less likely to cause resistance, whichas we’ll discuss next. 



For patients, the key practical difference between Xeomin and Botox is that Xeomin is much less likely to lead to resistance. =

With Botox, the complexing proteins in the product can lead to patients developing antibodies, so some patients may develop an immunity to it. This is rare and is more likely to occur with higher doses of Botox over a long period of time, but it’s still important to know about. On the other hand, Xeomin’s higher level of filtration is less likely to lead to resistance.



Another difference is stability. Given that Xeomin is a purer formula, it can be kept at room temperature while Botox needs to be refrigerated. 


Time on Market

Botox has been on the market as a medical treatment since 1989 and was approved as a cosmetic treatment in 2002. Xeomin received its FDA approval in 2010. In practice, Botox and Xeomin are incredibly similar and come from trusted manufacturers, so both are reliable options.


Which Is More Effective, Xeomin or Botox?

Xeomin and Botox are equally effective, especially when you first start getting anti-wrinkle injections. 

They work in the same way to inhibit muscle movement in a way that stops wrinkles in their tracks. Their strength, onset time, and longevity are comparable, so you can expect the same level of wrinkle-free smoothness no matter which one you choose. 

The key difference is resistance. There’s a reduced risk of developing resistance to Xeomin when compared to Botox, although this issue is rare even with Botox


Cost Comparison: Xeomin vs. Botox

At SEV, we charge the same for Xeomin and Botox. Depending on the location you visit, you can expect to pay as little as $12 per unit. The exact number of units you’ll need depends on the area you’re having treated and your desired results. If you’re interested in how much the cost will be, we recommend booking a consultation with one of our nurse providers

Regardless of which one you choose, Botox and Xeomin have the same level of potency, so you can expect to require a similar number of units. 

Both brands also offer rewards programs. The Allē program allows you to collect points and save on Botox as well as on fillers like Juvederm. Xperience+ is a rewards program that offers incentives and rewards to customers using Xeomin. 

You can also check out our Specials page to see if we have any promotions going on, so you can save on your Xeomin or Botox injection. 


Xeomin vs. Botox Aftercare

The aftercare process for Xeomin and Botox is identical: 

  • For at least 4 hours after your treatment, don’t bend over or lie down. 
  • Avoid rubbing or touching the treated area for 24 hours. 
  • Take it easy, and avoid exercising or other activities that can elevate your blood pressure for 24 hours after treatment. 
  • Don’t plan to have any laser hair removal or other treatments for at least 2 weeks after treatment. 
  • Avoid alcohol, non-steroidal, anti-inflammatories, and blood-thinning medications for 48 hours before and after your appointment, if approved by your doctor.


Botox and Xeomin Comparison Table 

Botox Xeomin
Effect Fades expression wrinkles by relaxing muscles Fades expression wrinkles by relaxing muscles
Production Filtration process leaves behind complexing proteins Double-filtered to remove complex proteins
Resistance In rare cases, patients may develop resistance Lower risk of resistance 
Rewards  Allē Rewards XPERIENCE Rewards
Time on market Staple that has been around since the ‘80s Newcomer received FDA approval in 2010

Xeomin and Botox Treatments at SEV

At SEV, our goal has always been to help our clients feel more confident and beautiful by using the most effective and scientifically advanced treatments. That’s why we’re thrilled to expand our injectable roster with Xeomin.

Whether you choose the classic Botox or newcomer Xeomin, know that our nurse injectors have the aesthetic experience to create precise, tailored results.

If you’re still not sure which is right for you, don’t hesitate to book a consultation or get in touch – we’ll be happy to help you choose the best injectable for you.